Inhibition of progesterone metabolism mimics the effect of progesterone withdrawal on forced swim test immobility
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15 صفحه اولAn anti-immobility effect of spermine in the forced swim test in mice.
BACKGROUND Spermine is one of the naturally occurring ligands that influence the function of the N-methyl-D-aspartate receptor. Similar to other endogenous polyamines present in micromolar concentration in the brain, it may play a role in the modulation of depression. Thus, the present study investigated the suggested antidepressant effect of spermine. METHODS The mouse forced swim test (FST)...
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The forced swim test (FST) is commonly employed to test the potency of drugs to reduce immobility as an indicator of anti-despair. Certainly, antidepressant drugs reduce the total time of immobility and enlarge the latency to the first immobility period. FST is preceded by the open field test (OFT) to discard any influence of changes in general motor activity that could interfere with immobilit...
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ژورنال
عنوان ژورنال: Pharmacology Biochemistry and Behavior
سال: 2007
ISSN: 0091-3057
DOI: 10.1016/j.pbb.2007.05.017